Brand/Other Name

Cefoperazone Sodium, Cefophar, Stabixin-1, Nupera, Bifotik, C-Razon, Cefomax, Cepraz, Logafox, Inzon, Ferzobat, Ceropid, Biorazon.

How it works

Cefoperazone belongs to a class of drugs called cephalosporin antibiotics. This drug works by stopping the growth of bacteria that cause infections.

Indication

Cefoperazone is used to treat certain infections caused by bacteria such as infections in the nose, throat, lungs, urinary tract, skin, bones, and joints.

Contraindications

People with a history of allergy to cefoperazone and other cephalosporin antibiotics should not use this medicine.

Side Effects

Cefoperazone antibiotics can cause side effects such as:

• Pain at the injection site
• Nausea and vomiting
• Skin rash
• Decrease in blood cell count
• Decreased hemoglobin levels
• Headache
• Fever accompanied by chills
• Increased liver enzyme levels

Preparation

Sefoperazon is available in the form of a 1 gram vial of injection powder which is given as an injection.

Dose

• Adults:
  • 2-4 grams per day in 2 divided doses
  • The dose may be increased to 12 grams per day in 2-4 divided doses for severe infections given by injection or infusion.
• Patients with renal impairment: 1-2 grams per day
• Patients with hepatic impairment: 4 grams per day

Security

Sefoperazon can only be given in clinics/hospitals under the supervision of a professional health worker. In patients with a history of allergy to penicillin-type antibiotics, decreased kidney function, and decreased liver function, administration of this drug must be accompanied by close monitoring.

Alcohol consumption is not recommended during treatment with sefoperazone because it may increase the risk of side effects such as flushing (redness on the skin, usually on the face), nausea, vomiting, and increased heart rate.

During pregnancy, this medication should be used only if absolutely necessary. Sefoperazone is excreted in breast milk in small amounts, so it should be used with caution during breastfeeding. Consult your doctor if you are breastfeeding to understand the balance of benefits and risks.

Drug Interactions

• Sefoperazon may increase the effect of drugs and the incidence of adverse effects of blood thinners (anticoagulants)
• The probenesid drug used as a high uric acid therapy can increase the level of sefaperazon in the blood.
• Sefoperazon is potentially fatal for increasing the risk of nephrotoxic (kidney damaging) if given with:
  • Aminoglycoside drugs (group of antibiotics)
  • Furosemide (a diuretic used to reduce excess fluid in the body caused by conditions such as heart failure, liver disease, and kidney disease)

Want to know information about other medicines? Check it out here, yes!