Brand/Other Name

Aciblock, Acran, Aldin, Anitid, Doranit, Gastridin, Getidin, Hexer, Hufadine, Radin.

How it works

Ranitidine works competitively in inhibiting histamine, a compound also produced in the stomach wall, so that it can inhibit gastric acid secretion and reduce the concentration of hydrogen ions in the stomach which is also acidic. 

Indication

Gastric ulcers and duodenal ulcers, GERD, chronic episodic dyspepsia, ulcers due to NSAIDs (anti-inflammatory drugs), duodenal ulcers due to bacterial infection H. Pylori, Zollinger-Ellison syndrome (a rare digestive disease where one or more tumors appear in the pancreas and duodenum), and other conditions where reduction of gastric acid will be beneficial.

Contraindications

History of allergy/hypersensitivity to ranitidine previously.

Side Effects

Headaches, constipation or diarrhea may occur. Tell your doctor immediately if you have any serious side effects, including: blurred vision, mental/mood changes (such as agitation/restlessness, confusion, depression, hallucinations), easy bleeding/bruising, breast enlargement, severe fatigue, fast/slow/irregular heartbeat, signs of infection (such as a persistent sore throat, fever, chills), severe abdominal pain, dark urine, yellowing of the skin/eyes. Very serious allergic reactions to this medicine are rare. However, seek medical help immediately if you experience symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and difficulty breathing.

Preparation

Tablet/capsule salut selaput (150/300 mg), syrup 60 ml, injection/injection.

Dose

• Oral adult dose: for mild gastric ulcers and duodenal ulcers 150 mg 2 times a day or 300 mg at night for 4-8 weeks, up to 6 weeks in chronic episodic dyspepsia, and up to 8 weeks in ulcers due to NSAIDs/anti-inflammatory drugs (in duodenal ulcers 300 mg can be given twice a day for 4 weeks to achieve a higher healing rate)
• Oral child dose: for gastric ulcer 2-4 mg/kgBW 2 times a day, maximum 300 mg a day. For Gastroesophageal Reflux Disease (GERD), 150 mg 2 times a day or 300 mg before bedtime for up to 8 weeks, or if necessary up to 12 weeks (up to weight, 600 mg a day in 2-4 divided doses for 12 weeks); long-term treatment of GERD, 150 mg 2 times a day. Zollinger-Ellison syndrome 150 mg 3 times a day; dose up to 6 g a day in divided doses.
• For use of injectable preparations and indications other than those mentioned at the oral dose, the dose will be determined by the doctor who is treating you.

Security

• Pregnancy category according to the FDA: category B. Studies in experimental animals have not shown a risk to the fetus, but there have been no controlled studies in humans.
• Ranitidine is excreted through breast milk. Consult your doctor before breastfeeding.

Drug Interactions

Some drugs require stomach acid for the body to absorb them properly. Ranitidine lowers the secretion of stomach acid, so it can reduce the effectiveness of this product. Some drugs that interact with ranitidine include atazanavir, dasatinib, delavirdine, certain azole antifungal drugs (such as itraconazole, ketoconazole), levoketoconazole, and pazopanib.